1JCQ

CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750

1JCQ の概要

• エントリーDOI: 10.2210/pdb1jcq/pdb
• 関連するPDBエントリー: 1D8D 1FT1 1JCR 1JCS
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: ftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, tumor regression, l-739, 750, peptidomimetic, inhibitor, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95055.03

構造登録者

Long, S.B.,Casey, P.J.,Beese, L.S. (登録日: 2001-06-11, 公開日: 2001-11-02, 最終更新日: 2023-08-16)

• 主引用文献: Long, S.B.,Hancock, P.J.,Kral, A.M.,Hellinga, H.W.,Beese, L.S.; The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.; Proc.Natl.Acad.Sci.USA, 98:12948-12953, 2001; PubMed: 11687658; DOI: 10.1073/pnas.241407898

実験手法

X-RAY DIFFRACTION (2.3 Å)