1IVQ
THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 WITH TWO SYNTHETIC PEPTIDIC TRANSITION STATE ANALOG INHIBITORS
1IVQ の概要
エントリーDOI | 10.2210/pdb1ivq/pdb |
関連するPDBエントリー | 1IVP |
関連するBIRD辞書のPRD_ID | PRD_000348 |
分子名称 | HIV-2 PROTEASE, N~1~-{(1S,2S,4S)-1-(cyclohexylmethyl)-4-[(2,2-dimethylpropyl)carbamoyl]-2-hydroxy-5-methylhexyl}-N~2~-(quinolin-2-ylcar bonyl)-L-aspartamide (3 entities in total) |
機能のキーワード | acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus 2 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04584 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22034.43 |
構造登録者 | |
主引用文献 | Mulichak, A.M.,Hui, J.O.,Tomasselli, A.G.,Heinrikson, R.L.,Curry, K.A.,Tomich, C.S.,Thaisrivongs, S.,Sawyer, T.K.,Watenpaugh, K.D. The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors. J.Biol.Chem., 268:13103-13109, 1993 Cited by PubMed: 8514751主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
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