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1IKY

HIV-1 Reverse Transcriptase in Complex with the Inhibitor MSC194

Summary for 1IKY
Entry DOI10.2210/pdb1iky/pdb
Related1EET 1HAR
DescriptorPOL POLYPROTEIN, 1-[2-(3-ACETYL-2-HYDROXY-6-METHOXY-PHENYL)-CYCLOPROPYL]-3-(5-CYANO-PYRIDIN-2-YL)-THIOUREA, ... (4 entities in total)
Functional Keywordsheterodimer, protein-inhibitor complex, transferase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
Total number of polymer chains2
Total formula weight114795.74
Authors
Lindberg, J.,Unge, T. (deposition date: 2001-05-07, release date: 2001-06-06, Last modification date: 2024-02-07)
Primary citationLindberg, J.,Sigurdsson, S.,Lowgren, S.,Andersson, H.O.,Sahlberg, C.,Noreen, R.,Fridborg, K.,Zhang, H.,Unge, T.
Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.
Eur.J.Biochem., 269:1670-1677, 2002
Cited by
PubMed: 11895437
DOI: 10.1046/j.1432-1327.2002.02811.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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