1EET

HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204

Summary for 1EET

• Entry DOI: 10.2210/pdb1eet/pdb
• Related: 1HAR
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE, 1-(5-BROMO-PYRIDIN-2-YL)-3-[2-(6-FLUORO-2-HYDROXY-3-PROPIONYL-PHENYL)-CYCLOPROPYL]-UREA, ... (4 entities in total)
• Functional Keywords: heterodimer, protein-inhibitor complex, viral protein, transferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 114510.22

Authors

Hogberg, M.,Sahlberg, C.,Engelhardt, P.,Noreen, R.,Kangasmetsa, J.,Johansson, N.G.,Oberg, B.,Vrang, L.,Zhang, H.,Sahlberg, B.L.,Unge, T.,Lovgren, S.,Fridborg, K.,Backbro, K. (deposition date: 2000-02-03, release date: 2001-02-07, Last modification date: 2024-02-07)

• Primary citation: Hogberg, M.,Sahlberg, C.,Engelhardt, P.,Noreen, R.,Kangasmetsa, J.,Johansson, N.G.,Oberg, B.,Vrang, L.,Zhang, H.,Sahlberg, B.L.,Unge, T.,Lovgren, S.,Fridborg, K.,Backbro, K.; Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.; J.Med.Chem., 42:4150-4160, 1999; PubMed: 10514285; DOI: 10.1021/jm990572y

Experimental method

X-RAY DIFFRACTION (2.73 Å)