1IIY

Solution NMR Structure of Complex of 1:2 Cyanovirin-N:Man-Alpha1,2-Man-Alpha Restrained Regularized Mean Coordinates

Summary for 1IIY

• Entry DOI: 10.2210/pdb1iiy/pdb
• Related PRD ID: PRD_900111
• Descriptor: CYANOVIRIN-N, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose (2 entities in total)
• Functional Keywords: hiv-inactivating protein, man-alpha1, 2-man-alpha, antiviral protein
• Biological source: Nostoc ellipsosporum
• Total number of polymer chains: 1
• Total formula weight: 11706.68

Authors

Bewley, C.A. (deposition date: 2001-04-24, release date: 2001-10-24, Last modification date: 2020-07-29)

Primary citation

Bewley, C.A.
Solution Structure of a Cyanovirin-N:Man alpha 1-2Man alpha Complex. Structural Basis for High Affinity Carbohydrate-Mediated Binding to gp120
Structure, 9:931-940, 2001

PubMed Abstract: Cyanovirin-N (CVN) is a novel, 11 kDa cyanobacterial protein that potently inhibits viral entry by diverse strains of HIV through high-affinity carbohydrate-mediated interactions with the viral envelope glycoprotein gp120. CVN contains two symmetry-related carbohydrate binding sites of differing affinities that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinities, the carbohydrates that also mediate CVN:gp120 binding. High-resolution structural studies of CVN in complex with a representative oligosaccharide are desirable for understanding the structural basis for this unprecedented specificity.

PubMed: 11591348
DOI: 10.1016/S0969-2126(01)00653-0

Experimental method

SOLUTION NMR