1IIP

Bovine Cyclophilin 40, Tetragonal Form

Summary for 1IIP

Entry DOI	10.2210/pdb1iip/pdb
Related	1IHG
Descriptor	Cyclophilin 40, GLYCEROL (3 entities in total)
Functional Keywords	ppiase immunophilin tetratricopeptide, isomerase
Biological source	Bos taurus (cattle)
Cellular location	Cytoplasm: P26882
Total number of polymer chains	1
Total formula weight	40770.41
Authors	Taylor, P.,Dornan, J.,Carrello, A.,Minchin, R.F.,Ratajczak, T.,Walkinshaw, M.D. (deposition date: 2001-04-24, release date: 2001-05-16, Last modification date: 2024-11-06)
Primary citation	Taylor, P.,Dornan, J.,Carrello, A.,Minchin, R.F.,Ratajczak, T.,Walkinshaw, M.D. Two structures of cyclophilin 40: folding and fidelity in the TPR domains. Structure, 9:431-438, 2001 Cited by PubMed Abstract: The "large immunophilin" family consists of domains of cyclophilin or FK506 binding protein linked to a tetratricopeptide (TPR) domain. They are intimately associated with steroid receptor complexes and bind to the C-terminal domain of Hsp90 via the TPR domain. The competitive binding of specific large immunophilins and other TPR-Hsp90 proteins provides a regulatory mechanism for Hsp90 chaperone activity. PubMed: 11377203 DOI: 10.1016/S0969-2126(01)00603-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation