1IIP
Bovine Cyclophilin 40, Tetragonal Form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005929 | cellular_component | cilium |
| A | 0006457 | biological_process | protein folding |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0015031 | biological_process | protein transport |
| A | 0016018 | molecular_function | cyclosporin A binding |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030331 | molecular_function | nuclear estrogen receptor binding |
| A | 0030544 | molecular_function | Hsp70 protein binding |
| A | 0031072 | molecular_function | heat shock protein binding |
| A | 0034389 | biological_process | lipid droplet organization |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0045070 | biological_process | positive regulation of viral genome replication |
| A | 0050714 | biological_process | positive regulation of protein secretion |
| A | 0051879 | molecular_function | Hsp90 protein binding |
| A | 0061077 | biological_process | obsolete chaperone-mediated protein folding |
| A | 0065003 | biological_process | protein-containing complex assembly |
| A | 0071492 | biological_process | cellular response to UV-A |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 371 |
| Chain | Residue |
| A | ASP204 |
| A | LYS244 |
| A | ARG251 |
| A | HOH401 |
| A | HOH451 |
| A | HOH574 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. FkgCpFHRIIkkFMiQGG |
| Chain | Residue | Details |
| A | PHE68-GLY85 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 164 |
| Details | Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Region: {"description":"Chaperone activity"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q08752","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CR16","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
