1I9R

STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY

1I9R の概要

• エントリーDOI: 10.2210/pdb1i9r/pdb
• 分子名称: CD40 LIGAND, IMMUNOGLOBULIN H, IMMUNOGLOBULIN L, ... (4 entities in total)
• 機能のキーワード: beta-sheet sandwich, immunoglobulin, cytokine-immune system complex, cytokine/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted: P29965
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 189191.30

構造登録者

Karpusas, M.,Lucci, J.,Ferrant, J.,Benjamin, C.,Hsu, Y.-M. (登録日: 2001-03-20, 公開日: 2002-03-20, 最終更新日: 2024-11-06)

主引用文献

Karpusas, M.,Lucci, J.,Ferrant, J.,Benjamin, C.,Taylor, F.R.,Strauch, K.,Garber, E.,Hsu, Y.M.
Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody.
Structure, 9:321-329, 2001

PubMed Abstract: CD40 ligand (CD40L or CD154), a member of the tumor necrosis factor (TNF) family, plays a critical role in both humoral and cellular immune responses and has been implicated in biological pathways involving epithelial cells, fibroblasts, and platelets. Such a pathway is T cell-mediated B cell activation, a process that occurs through the interaction of CD40L with CD40 receptor expressed on B cells. It results in various B cell responses, including immunoglobulin isotype switching and B cell differentiation and proliferation. These responses can be inhibited by the monoclonal antibody 5c8, which binds with high affinity to CD40L.

PubMed: 11525169
DOI: 10.1016/S0969-2126(01)00590-1

実験手法

X-RAY DIFFRACTION (3.1 Å)