1I7S

ANTHRANILATE SYNTHASE FROM SERRATIA MARCESCENS IN COMPLEX WITH ITS END PRODUCT INHIBITOR L-TRYPTOPHAN

Summary for 1I7S

Entry DOI	10.2210/pdb1i7s/pdb
Descriptor	ANTHRANILATE SYNTHASE, TRPG, TRYPTOPHAN (3 entities in total)
Functional Keywords	anthranilate synthase, end product inhibition, tryptophan binding, conformational change, lyase
Biological source	Serratia marcescens More
Total number of polymer chains	4
Total formula weight	157637.23
Authors	Spraggon, G.,Kim, C.,Nguyen-Huu, X.,Yee, M.-C.,Yanofsky, C.,Mills, S.E. (deposition date: 2001-03-10, release date: 2001-05-16, Last modification date: 2023-08-09)
Primary citation	Spraggon, G.,Kim, C.,Nguyen-Huu, X.,Yee, M.C.,Yanofsky, C.,Mills, S.E. The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc.Natl.Acad.Sci.USA, 98:6021-6026, 2001 Cited by PubMed: 11371633 DOI: 10.1073/pnas.111150298 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation