1I7S
ANTHRANILATE SYNTHASE FROM SERRATIA MARCESCENS IN COMPLEX WITH ITS END PRODUCT INHIBITOR L-TRYPTOPHAN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004049 | molecular_function | anthranilate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0002047 | biological_process | phenazine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| B | 0004049 | molecular_function | anthranilate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004049 | molecular_function | anthranilate synthase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0002047 | biological_process | phenazine biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| D | 0004049 | molecular_function | anthranilate synthase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TRP A 601 |
| Chain | Residue |
| A | LEU38 |
| A | GLY454 |
| A | TYR455 |
| A | ASP463 |
| A | GLU39 |
| A | SER40 |
| A | LEU49 |
| A | GLN50 |
| A | PRO291 |
| A | TYR292 |
| A | MET293 |
| A | VAL453 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRP C 701 |
| Chain | Residue |
| C | LEU38 |
| C | GLU39 |
| C | SER40 |
| C | LEU49 |
| C | GLN50 |
| C | PRO291 |
| C | TYR292 |
| C | MET293 |
| C | VAL453 |
| C | ASP463 |
| C | CYS465 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1I7S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 380 |
| Details | Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00605","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for GATase activity","evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For GATase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00605","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| A | HIS398 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| C | HIS398 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| B | HIS172 | |
| B | CYS85 | |
| B | GLU174 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| D | HIS172 | |
| D | CYS85 | |
| D | GLU174 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| B | HIS172 | |
| B | CYS85 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bxr |
| Chain | Residue | Details |
| D | HIS172 | |
| D | CYS85 |
