1I7G

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN FROM HUMAN PPAR-ALPHA IN COMPLEX WITH THE AGONIST AZ 242

1I7G の概要

• エントリーDOI: 10.2210/pdb1i7g/pdb
• 関連するPDBエントリー: 1I7I
• 分子名称: PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA, SODIUM ION, (2S)-2-ETHOXY-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENYL}ETHOXY)PHENYL]PROPANOIC ACID, ... (5 entities in total)
• 機能のキーワード: anti parallel helix sandwich, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q07869
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33630.86

構造登録者

Petersen, J.F.W.,Cronet, P.,Folmer, R.,Blomberg, N.,Sjoblom, K.,Karlsson, U.,Lindstedt, E.-L.,Bamberg, K. (登録日: 2001-03-09, 公開日: 2002-03-09, 最終更新日: 2023-08-09)

主引用文献

Cronet, P.,Petersen, J.F.,Folmer, R.,Blomberg, N.,Sjoblom, K.,Karlsson, U.,Lindstedt, E.L.,Bamberg, K.
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
Structure, 9:699-706, 2001

PubMed Abstract: The peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors belonging to the nuclear receptor family. The roles of PPARalpha in fatty acid oxidation and PPARgamma in adipocyte differentiation and lipid storage have been characterized extensively. PPARs are activated by fatty acids and eicosanoids and are also targets for antidyslipidemic drugs, but the molecular interactions governing ligand selectivity for specific subtypes are unclear due to the lack of a PPARalpha ligand binding domain structure.

PubMed: 11587644
DOI: 10.1016/S0969-2126(01)00634-7

実験手法

X-RAY DIFFRACTION (2.2 Å)