1I76
COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Summary for 1I76
Entry DOI | 10.2210/pdb1i76/pdb |
Related | 1BZS 1I73 1JAP |
Descriptor | NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase, complex (metalloprotease-inhibitor) |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 1 |
Total formula weight | 18716.17 |
Authors | Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A. (deposition date: 2001-03-08, release date: 2001-03-21, Last modification date: 2023-08-09) |
Primary citation | Gavuzzo, E.,Pochetti, G.,Mazza, F.,Gallina, C.,Gorini, B.,D'Alessio, S.,Pieper, M.,Tschesche, H.,Tucker, P.A. Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J.Med.Chem., 43:3377-3385, 2000 Cited by PubMed: 10978185DOI: 10.1021/jm9909589 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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