1BZS

CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909

Summary for 1BZS

DescriptorNEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywordsmetallo proteinase, hydroxamate, matrix degradation, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasmic granule P22894
Total number of polymer chains1
Total molecular weight19216.74
Authors
Schreuder, H.,Brachvogel, V.,Loenze, P. (deposition date: 1998-11-04, release date: 2000-05-31, Last modification date: 2011-07-13)
Primary citation
Matter, H.,Schwab, W.,Barbier, D.,Billen, G.,Haase, B.,Neises, B.,Schudok, M.,Thorwart, W.,Schreuder, H.,Brachvogel, V.,Lonze, P.,Weithmann, K.U.
Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis.
J.Med.Chem., 42:1908-1920, 1999
PubMed: 10354399 (PDB entries with the same primary citation)
DOI: 10.1021/jm980631s
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers301.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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