1HVY

Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation

1HVY の概要

分子名称THYMIDYLATE SYNTHASE, TOMUDEX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
機能のキーワードtomudex, raltitrexed, transferase
由来する生物種Homo sapiens (human)
細胞内の位置Nucleus  P04818
ポリマー鎖数4
分子量合計135827.09
構造登録者
Phan, J.,Koli, S.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. (登録日: 2001-01-08, 公開日: 2001-01-31, 最終更新日: 2017-10-04)
主引用文献
Phan, J.,Koli, S.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L.
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug
Biochemistry, 40:1897-1902, 2001
PubMed: 11329255 (主引用文献が同じPDBエントリー)
DOI: 10.1021/bi002413i
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.9 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24690.4%2.1%1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード