1HVY

Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation

1HVY の概要

• エントリーDOI: 10.2210/pdb1hvy/pdb
• 分子名称: THYMIDYLATE SYNTHASE, TOMUDEX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: tomudex, raltitrexed, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P04818
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 135827.09

構造登録者

Phan, J.,Koli, S.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. (登録日: 2001-01-08, 公開日: 2001-01-31, 最終更新日: 2022-04-13)

• 主引用文献: Phan, J.,Koli, S.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L.; Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug; Biochemistry, 40:1897-1902, 2001; PubMed: 11329255; DOI: 10.1021/bi002413i

実験手法

X-RAY DIFFRACTION (1.9 Å)