1HVK

INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE

Summary for 1HVK

• Entry DOI: 10.2210/pdb1hvk/pdb
• Descriptor: HIV-1 PROTEASE, N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE (3 entities in total)
• Functional Keywords: hydrolase(acid protease)
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• Total number of polymer chains: 2
• Total formula weight: 22402.49

Authors

Bhat, T.N.,Hosur, M.V.,Baldwin, E.T.,Erickson, J.W. (deposition date: 1994-01-26, release date: 1994-04-30, Last modification date: 2024-02-07)

• Primary citation: Hosur, M.V.,Bhat, T.N.,Kempf, D.,Baldwin, E.T.,Liu, B.,Gulnik, S.,Wideburg, N.E.,Norbeck, D.W.,Appelt, K.,Erickson, J.W.; Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease; J.Am.Chem.Soc., 116:847-855, 1994

Experimental method

X-RAY DIFFRACTION (1.8 Å)