1HPV

CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME

Summary for 1HPV

• Entry DOI: 10.2210/pdb1hpv/pdb
• Descriptor: HIV-1 PROTEASE, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total)
• Functional Keywords: hydrolase (acid proteinase)
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• Total number of polymer chains: 2
• Total formula weight: 22113.14

Authors

Kim, E.E. (deposition date: 1994-11-18, release date: 1995-03-31, Last modification date: 2024-02-07)

• Primary citation: Kim, E.E.,Baker, C.T.,Dwyer, M.D.,Murcko, M.A.,Rao, B.G.,Tung, R.D.,Navia, M.A.; Crystal Structure of HIV-1 Protease in Complex with Vx-478, a Potent and Orally Bioavailable Inhibitor of the Enzyme; J.Am.Chem.Soc., 117:1181-1182, 1995

Experimental method

X-RAY DIFFRACTION (1.9 Å)