Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1HPV

CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME

Summary for 1HPV
Entry DOI10.2210/pdb1hpv/pdb
DescriptorHIV-1 PROTEASE, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total)
Functional Keywordshydrolase (acid proteinase)
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains2
Total formula weight22113.14
Authors
Kim, E.E. (deposition date: 1994-11-18, release date: 1995-03-31, Last modification date: 2024-02-07)
Primary citationKim, E.E.,Baker, C.T.,Dwyer, M.D.,Murcko, M.A.,Rao, B.G.,Tung, R.D.,Navia, M.A.
Crystal Structure of HIV-1 Protease in Complex with Vx-478, a Potent and Orally Bioavailable Inhibitor of the Enzyme
J.Am.Chem.Soc., 117:1181-1182, 1995
Cited by
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon