1HNW

STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE

Summary for 1HNW

• Entry DOI: 10.2210/pdb1hnw/pdb
• Related: 1FJF 1FJG 1HNX 1HNZ 1QD7
• Descriptor: 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S9, 30S RIBOSOMAL PROTEIN S10, ... (25 entities in total)
• Functional Keywords: 30s ribosomal subunit, ribosome, antibiotic, tetracycline
• Biological source: Thermus thermophilus; More
• Total number of polymer chains: 22
• Total formula weight: 788679.84

Authors

Brodersen, D.E.,Clemons Jr., W.M.,Carter, A.P.,Morgan-Warren, R.,Wimberly, B.T.,Ramakrishnan, V. (deposition date: 2000-12-08, release date: 2001-02-21, Last modification date: 2024-10-30)

Primary citation

Brodersen, D.E.,Clemons Jr., W.M.,Carter, A.P.,Morgan-Warren, R.J.,Wimberly, B.T.,Ramakrishnan, V.
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Cell(Cambridge,Mass.), 103:1143-1154, 2000

PubMed Abstract: We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.

PubMed: 11163189
DOI: 10.1016/S0092-8674(00)00216-6

Experimental method

X-RAY DIFFRACTION (3.4 Å)