1HFS
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-764,004
Summary for 1HFS
Entry DOI | 10.2210/pdb1hfs/pdb |
Descriptor | STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase, metalloprotease, matrix metalloprotease-3, proteoglycanase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P08254 |
Total number of polymer chains | 1 |
Total formula weight | 18902.83 |
Authors | Becker, J.W. (deposition date: 1997-02-13, release date: 1998-02-18, Last modification date: 2024-02-07) |
Primary citation | Esser, C.K.,Bugianesi, R.L.,Caldwell, C.G.,Chapman, K.T.,Durette, P.L.,Girotra, N.N.,Kopka, I.E.,Lanza, T.J.,Levorse, D.A.,MacCoss, M.,Owens, K.A.,Ponpipom, M.M.,Simeone, J.P.,Harrison, R.K.,Niedzwiecki, L.,Becker, J.W.,Marcy, A.I.,Axel, M.G.,Christen, A.J.,McDonnell, J.,Moore, V.L.,Olszewski, J.M.,Saphos, C.,Visco, D.M.,Shen, F.,Colletti, A.,Krieter, P.A.,Hagmann, W.K. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J.Med.Chem., 40:1026-1040, 1997 Cited by PubMed: 9083493DOI: 10.1021/jm960465t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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