1HFS

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THE N-CARBOXY-ALKYL INHIBITOR L-764,004

Summary for 1HFS

Entry DOI	10.2210/pdb1hfs/pdb
Descriptor	STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, metalloprotease, matrix metalloprotease-3, proteoglycanase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P08254
Total number of polymer chains	1
Total formula weight	18902.83
Authors	Becker, J.W. (deposition date: 1997-02-13, release date: 1998-02-18, Last modification date: 2024-02-07)
Primary citation	Esser, C.K.,Bugianesi, R.L.,Caldwell, C.G.,Chapman, K.T.,Durette, P.L.,Girotra, N.N.,Kopka, I.E.,Lanza, T.J.,Levorse, D.A.,MacCoss, M.,Owens, K.A.,Ponpipom, M.M.,Simeone, J.P.,Harrison, R.K.,Niedzwiecki, L.,Becker, J.W.,Marcy, A.I.,Axel, M.G.,Christen, A.J.,McDonnell, J.,Moore, V.L.,Olszewski, J.M.,Saphos, C.,Visco, D.M.,Shen, F.,Colletti, A.,Krieter, P.A.,Hagmann, W.K. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J.Med.Chem., 40:1026-1040, 1997 Cited by PubMed: 9083493 DOI: 10.1021/jm960465t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation