1HEF

The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations

Summary for 1HEF

Entry DOI	10.2210/pdb1hef/pdb
Related PRD ID	PRD_000319
Descriptor	HIV-1 PROTEASE, SKF 108738 PEPTIDE INHIBITOR (3 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
Total number of polymer chains	2
Total formula weight	11454.50
Authors	Murthy, K.,Winborne, E.L.,Minnich, M.D.,Culp, J.S.,Debouck, C. (deposition date: 1992-09-21, release date: 1994-05-31, Last modification date: 2023-11-15)
Primary citation	Murthy, K.H.,Winborne, E.L.,Minnich, M.D.,Culp, J.S.,Debouck, C. The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. J.Biol.Chem., 267:22770-22778, 1992 Cited by PubMed: 1429626 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation