1HCQ

THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS

Summary for 1HCQ

DescriptorDNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP*CP*CP*T P*G)-3'), DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (ESTROGEN RECEPTOR), ... (5 entities in total)
Functional Keywordsprotein-dna complex, complexed with drug, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Nucleus. Isoform 3: Nucleus P03372
Total number of polymer chains8
Total molecular weight61356.59
Authors
Schwabe, J.W.R.,Chapman, L.,Finch, J.T.,Rhodes, D. (deposition date: 1995-01-04, release date: 1995-11-23, Last modification date: 2011-07-13)
Primary citation
Schwabe, J.W.,Chapman, L.,Finch, J.T.,Rhodes, D.
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
Cell(Cambridge,Mass.), 75:567-578, 1993
PubMed: 8221895 (PDB entries with the same primary citation)
DOI: 10.1016/0092-8674(93)90390-C
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers231.1%12.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 1hcq
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1hcq.pdb2.gz [40.36 KB])
Coordinate files for Biological unit (1hcq.pdb1.gz [41.56 KB])