1HCF

Crystal structure of TrkB-d5 bound to neurotrophin-4/5

1HCF の概要

• エントリーDOI: 10.2210/pdb1hcf/pdb
• 関連するPDBエントリー: 1B8M 1B98 1WWB
• 分子名称: NEUROTROPHIN-4, BDNF/NT-3 GROWTH FACTORS RECEPTOR, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: transferase/hormone, complex(transferase-growth factor), neurotrophin-4/5, trkb receptor, ngf-beta superfamily, immunoglobulin domain, transferase-hormone complex
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted: P34130; Membrane; Single-pass type I membrane protein: Q16620
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 51365.50

構造登録者

Banfield, M.J.,Naylor, R.L.,Robertson, A.G.S.,Allen, S.J.,Dawbarn, D.,Brady, R.L. (登録日: 2001-05-03, 公開日: 2001-12-06, 最終更新日: 2024-11-06)

主引用文献

Banfield, M.J.,Naylor, R.L.,Robertson, A.G.S.,Allen, S.J.,Dawbarn, D.,Brady, R.L.
Specificity in Trk-Receptor:Neurotrophin Interaction: The Crystal Structure of Trkb-D5 in Complex with Neurotrophin-4/5
Structure, 9:1191-, 2001

PubMed Abstract: The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of Trk receptor:neurotrophin interaction. Neurotrophin function has been implicated in a number of neurological disorders, including Alzheimer's disease and Parkinson's disease.

PubMed: 11738045
DOI: 10.1016/S0969-2126(01)00681-5

実験手法

X-RAY DIFFRACTION (2.7 Å)