1H1B

Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151)

Summary for 1H1B

• Entry DOI: 10.2210/pdb1h1b/pdb
• Related: 1B0F 1HNE 1PPF 1PPG
• Descriptor: LEUKOCYTE ELASTASE, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2S)-3-METHYL-2-((2R,3S)-3-[(METHYLSULFONYL)AMINO]-1-{[2-(PYRROLIDIN-1-YLMETHYL)-1,3-OXAZOL-4-YL]CARBONYL}PYRROLIDIN-2-YL)BUTANOIC ACID, ... (4 entities in total)
• Functional Keywords: hydrolase, serine protease
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 48992.42

Authors

Macdonald, S.J.F.,Dowle, M.D.,Harrison, L.A.,Clarke, G.D.E.,Inglis, G.G.A.,Johnson, M.R.,Smith, R.A.,Amour, A.,Fleetwood, G.,Humphreys, D.C.,Molloy, C.R.,Dixon, M.,Godward, R.E.,Wonacott, A.J.,Singh, O.M.P.,Hodgson, S.T.,Hardy, G.W. (deposition date: 2002-07-05, release date: 2002-08-29, Last modification date: 2023-12-13)

• Primary citation: Macdonald, S.J.F.,Dowle, M.D.,Harrison, L.A.,Clarke, G.D.E.,Inglis, G.G.A.,Johnson, M.R.,Shah, P.,Smith, R.A.,Amour, A.,Fleetwood, G.,Humphreys, D.C.,Molloy, C.R.,Dixon, M.,Godward, R.E.,Wonacott, A.J.,Singh, O.M.P.,Hodgson, S.T.,Hardy, G.W.; Discovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151); J.Med.Chem., 45:3878-, 2002; PubMed: 12190311; DOI: 10.1021/JM020881F

Experimental method

X-RAY DIFFRACTION (2 Å)