1B0F
CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE WITH MDL 101, 146
Summary for 1B0F
Entry DOI | 10.2210/pdb1b0f/pdb |
Descriptor | PROTEIN (ELASTASE), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1-{3-METHYL-2-[4-(MORPHOLINE-4-CARBONYL)-BENZOYLAMINO]-BUTYRYL}-PYRROLIDINE-2-CARBOXYLIC ACID (3,3,4,4,4-PENTAFLUORO-1-ISOPROPYL-2-OXO-BUTYL)-AMIDE, ... (4 entities in total) |
Functional Keywords | serine protease, fluoroethyl ketones, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 25007.55 |
Authors | Schreuder, H.A.,Metz, W.A.,Peet, N.P.,Pelton, J.T.,Tardif, C. (deposition date: 1998-11-09, release date: 1998-11-09, Last modification date: 2023-08-09) |
Primary citation | Cregge, R.J.,Durham, S.L.,Farr, R.A.,Gallion, S.L.,Hare, C.M.,Hoffman, R.V.,Janusz, M.J.,Kim, H.O.,Koehl, J.R.,Mehdi, S.,Metz, W.A.,Peet, N.P.,Pelton, J.T.,Schreuder, H.A.,Sunder, S.,Tardif, C. Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones. J.Med.Chem., 41:2461-2480, 1998 Cited by PubMed: 9651152DOI: 10.1021/jm970812e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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