1GZH
Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor
Summary for 1GZH
Entry DOI | 10.2210/pdb1gzh/pdb |
Related | 1A1U 1AIE 1DT7 1HS5 1KZY 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1YCQ 1YCS 3SAK |
Descriptor | CELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION, ... (6 entities in total) |
Functional Keywords | gene regulation, anti-oncogene, dna-binding, transcription regulation, bcrt domain, apoptosis, disease mutation, activator, dna- repair |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 P04637 Nucleus: Q12888 |
Total number of polymer chains | 4 |
Total formula weight | 101411.68 |
Authors | Derbyshire, D.J.,Doherty, A.J. (deposition date: 2002-05-22, release date: 2002-06-27, Last modification date: 2023-12-13) |
Primary citation | Derbyshire, D.J.,Basu, B.P.,Serpell, L.,Joo, W.,Date, T.,Iwabuchi, K.,Doherty, A.J. Crystal Structure of Human 53BP1 Brct Domains Bound to P53 Tumour Suppressor Embo J., 21:3863-, 2002 Cited by PubMed: 12110597DOI: 10.1093/EMBOJ/CDF383 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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