1GZH

Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor

1GZH の概要

• エントリーDOI: 10.2210/pdb1gzh/pdb
• 関連するPDBエントリー: 1A1U 1AIE 1DT7 1HS5 1KZY 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1YCQ 1YCS 3SAK
• 分子名称: CELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION, ... (6 entities in total)
• 機能のキーワード: gene regulation, anti-oncogene, dna-binding, transcription regulation, bcrt domain, apoptosis, disease mutation, activator, dna- repair
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 P04637; Nucleus: Q12888
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101411.68

構造登録者

Derbyshire, D.J.,Doherty, A.J. (登録日: 2002-05-22, 公開日: 2002-06-27, 最終更新日: 2023-12-13)

• 主引用文献: Derbyshire, D.J.,Basu, B.P.,Serpell, L.,Joo, W.,Date, T.,Iwabuchi, K.,Doherty, A.J.; Crystal Structure of Human 53BP1 Brct Domains Bound to P53 Tumour Suppressor; Embo J., 21:3863-, 2002; PubMed: 12110597; DOI: 10.1093/EMBOJ/CDF383

実験手法

X-RAY DIFFRACTION (2.6 Å)