1GS4

Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer

1GS4 の概要

• エントリーDOI: 10.2210/pdb1gs4/pdb
• 関連するPDBエントリー: 1E3G
• 分子名称: ANDROGEN RECEPTOR, 9ALPHA-FLUOROCORTISOL, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: androgen receptor, human androgen receptor, ligand-binding domain, cortisol/ cortisone response, prostate cancer
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29415.36

構造登録者

Matias, P.M.,Carrondo, M.A.,Coelho, R.,Thomaz, M.,Zhao, X.-Y.,Wegg, A.,Crusius, K.,Egner, U.,Donner, P. (登録日: 2001-12-27, 公開日: 2003-01-16, 最終更新日: 2023-12-13)

• 主引用文献: Matias, P.M.,Carrondo, M.A.,Coelho, R.,Thomaz, M.,Zhao, X.-Y.,Wegg, A.,Crusius, K.,Egner, U.,Donner, P.; Structural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (Ar(Ccr)) Derived from an Androgen-Independent Prostate Cancer; J.Med.Chem., 45:1439-1446, 2002; PubMed: 11906285; DOI: 10.1021/JM011072J

実験手法

X-RAY DIFFRACTION (1.95 Å)