1GOT

HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS

1GOT の概要

• エントリーDOI: 10.2210/pdb1got/pdb
• 分子名称: GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ... (5 entities in total)
• 機能のキーワード: complex (gtp-binding-transducer), g protein, heterotrimer signal transduction, complex (gtp-binding-transducer) complex, complex (gtp-binding/transducer)
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P02698
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 87138.46

構造登録者

Lambright, D.G.,Sondek, J.,Bohm, A.,Skiba, N.P.,Hamm, H.E.,Sigler, P.B. (登録日: 1996-08-07, 公開日: 1997-03-12, 最終更新日: 2024-10-16)

主引用文献

Lambright, D.G.,Sondek, J.,Bohm, A.,Skiba, N.P.,Hamm, H.E.,Sigler, P.B.
The 2.0 A crystal structure of a heterotrimeric G protein.
Nature, 379:311-319, 1996

PubMed Abstract: The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.

PubMed: 8552184
DOI: 10.1038/379311a0

実験手法

X-RAY DIFFRACTION (2 Å)