1GNM
HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
Summary for 1GNM
Entry DOI | 10.2210/pdb1gnm/pdb |
Descriptor | HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE (3 entities in total) |
Functional Keywords | aspartic protease, hiv, mutant, inhibitor, u-89360e, hydrolase (acid protease) |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22832.95 |
Authors | Hong, L.,Treharne, A.,Hartsuck, J.A.,Foundling, S.,Tang, J. (deposition date: 1996-05-04, release date: 1996-11-08, Last modification date: 2024-02-07) |
Primary citation | Hong, L.,Treharne, A.,Hartsuck, J.A.,Foundling, S.,Tang, J. Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases. Biochemistry, 35:10627-10633, 1996 Cited by PubMed: 8718851DOI: 10.1021/bi960481s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report