1GKC

MMP9-inhibitor complex

Summary for 1GKC

Descriptor92 KDA TYPE IV COLLAGENASE, CALCIUM ION, N~2~-[(2R)-2-{[formyl(hydroxy)amino]methyl}-4-methylpentanoyl]-N,3-dimethyl-L-valinamide, ... (5 entities in total)
Functional Keywordsmatrix metalloprotease, hydrolase, glycoprotein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted, extracellular space, extracellular matrix (Probable) P14780
Total number of polymer chains2
Total molecular weight38062.05
Authors
Rowsell, S.,Pauptit, R.A. (deposition date: 2001-08-10, release date: 2002-05-16, Last modification date: 2011-07-13)
Primary citation
Rowsell, S.,Hawtin, P.,Minshull, C.A.,Jepson, H.,Brockbank, S.,Barratt, D.,Slater, A.M.,Mcpheat, W.,Waterson, D.,Henney, A.,Pauptit, R.A.
Crystal Structure of Mmp9 in Complex with a Reverse Hydroxamate Inhibitor
J.Mol.Biol., 319:173-, 2002
PubMed: 12051944 (PDB entries with the same primary citation)
DOI: 10.1016/S0022-2836(02)00262-0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.237802.4%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution