Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1444 |
| Chain | Residue |
| A | ASP182 |
| A | GLY183 |
| A | ASP185 |
| A | LEU187 |
| A | ASP205 |
| A | GLU208 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1445 |
| Chain | Residue |
| A | ASP201 |
| A | HOH2028 |
| A | HOH2039 |
| A | ASP165 |
| A | GLY197 |
| A | GLN199 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 1446 |
| Chain | Residue |
| A | ASP131 |
| A | ASP206 |
| A | GLU208 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1447 |
| Chain | Residue |
| A | SER211 |
| A | LEU212 |
| A | GLY213 |
| A | LYS214 |
| A | GLY215 |
| A | HOH2047 |
| A | HOH2050 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NFH A 1448 |
| Chain | Residue |
| A | GLY186 |
| A | LEU187 |
| A | LEU188 |
| A | ALA189 |
| A | TYR393 |
| A | HIS401 |
| A | GLU402 |
| A | HIS405 |
| A | HIS411 |
| A | PRO421 |
| A | MET422 |
| A | TYR423 |
| A | ZN1450 |
| A | HOH2038 |
| A | HOH2056 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1450 |
| Chain | Residue |
| A | HIS401 |
| A | HIS405 |
| A | HIS411 |
| A | NFH1448 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1451 |
| Chain | Residue |
| A | HIS175 |
| A | ASP177 |
| A | HIS190 |
| A | HIS203 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 1452 |
| Chain | Residue |
| A | SER149 |
| A | HOH2021 |
| A | HOH2022 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1444 |
| Chain | Residue |
| B | ASP182 |
| B | GLY183 |
| B | ASP185 |
| B | LEU187 |
| B | ASP205 |
| B | GLU208 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1445 |
| Chain | Residue |
| B | ASP165 |
| B | GLY197 |
| B | GLN199 |
| B | ASP201 |
| B | HOH2030 |
| B | HOH2041 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 1446 |
| Chain | Residue |
| B | ASP131 |
| B | ASP206 |
| B | GLU208 |
| B | HOH2011 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1447 |
| Chain | Residue |
| B | SER211 |
| B | LEU212 |
| B | GLY213 |
| B | LYS214 |
| B | GLN391 |
| B | HOH2052 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 1448 |
| Chain | Residue |
| B | SER149 |
| B | THR152 |
| B | HOH2021 |
| B | HOH2022 |
| site_id | BC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NFH B 1449 |
| Chain | Residue |
| B | GLY186 |
| B | LEU187 |
| B | LEU188 |
| B | ALA189 |
| B | TYR393 |
| B | HIS401 |
| B | GLU402 |
| B | HIS405 |
| B | HIS411 |
| B | TYR420 |
| B | PRO421 |
| B | MET422 |
| B | TYR423 |
| B | ZN1451 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1451 |
| Chain | Residue |
| B | HIS401 |
| B | HIS405 |
| B | HIS411 |
| B | NFH1449 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1452 |
| Chain | Residue |
| B | HIS175 |
| B | ASP177 |
| B | HIS190 |
| B | HIS203 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAL |
| Chain | Residue | Details |
| A | VAL398-LEU407 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12077439","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | MET419 | |
| A | GLU402 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | MET419 | |
| B | GLU402 | |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU402 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU402 | |
