1GJA

ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS

Summary for 1GJA

• Entry DOI: 10.2210/pdb1gja/pdb
• Related: 1C5X
• Descriptor: UROKINASE-TYPE PLASMINOGEN ACTIVATOR, CITRIC ACID, N-(4-CARBAMIMIDOYL-PHENYL)-2-HYDROXY-BENZAMIDE, ... (5 entities in total)
• Functional Keywords: selectivity at s1, h2o displacement, upa, tpa, ser190/ala190 protease, structure-based drug design, blood clotting, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00749 P00749
• Total number of polymer chains: 2
• Total formula weight: 31783.13

Authors

Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L. (deposition date: 2001-04-27, release date: 2002-04-27, Last modification date: 2023-12-27)

• Primary citation: Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Elrod, K.,Kirtley, M.,Janc, J.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L.; Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.; Chem.Biol., 8:1107-1121, 2001; PubMed: 11731301; DOI: 10.1016/S1074-5521(01)00084-9

Experimental method

X-RAY DIFFRACTION (1.56 Å)