1GIJ
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
Summary for 1GIJ
Entry DOI | 10.2210/pdb1gij/pdb |
Related | 1GIH 1GII |
Descriptor | CELL DIVISION PROTEIN KINASE 2, 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA (3 entities in total) |
Functional Keywords | protein kinase, cell cycle, inhibition, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34291.78 |
Authors | Ikuta, M.,Nishimura, S. (deposition date: 2001-02-06, release date: 2002-02-06, Last modification date: 2023-12-27) |
Primary citation | Ikuta, M.,Kamata, K.,Fukasawa, K.,Honma, T.,Machida, T.,Hirai, H.,Suzuki-Takahashi, I.,Hayama, T.,Nishimura, S. Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein. J.Biol.Chem., 276:27548-27554, 2002 Cited by PubMed: 11335721DOI: 10.1074/jbc.M102060200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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