1GIJ
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CELL DIVISION PROTEIN KINASE 2 | polymer | 298 | 33925.4 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | CYCLIN DEPENDENT KINASE 2 |
| 2 | B (A) | 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA | non-polymer | 366.4 | 1 | Chemie (2PU) | |||
| 3 | C (A) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| His 82 | Phe 82 | engineered mutation |
| Val 83 | Leu 83 | engineered mutation |
| Thr 89 | Lys 89 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33925.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 366.4 | |
| All* | Total formula weight | 34291.8 |
