1GEF

Crystal structure of the archaeal holliday junction resolvase HJC

Summary for 1GEF

Entry DOI	10.2210/pdb1gef/pdb
Descriptor	HOLLIDAY JUNCTION RESOLVASE, SULFATE ION (3 entities in total)
Functional Keywords	holliday junction resolvase, hjc, hydrolase
Biological source	Pyrococcus furiosus
Total number of polymer chains	4
Total formula weight	55361.64
Authors	Nishino, T.,Komori, K.,Tsuchiya, D.,Ishino, Y.,Morikawa, K. (deposition date: 2000-11-08, release date: 2001-03-21, Last modification date: 2023-12-27)
Primary citation	Nishino, T.,Komori, K.,Tsuchiya, D.,Ishino, Y.,Morikawa, K. Crystal structure of the archaeal holliday junction resolvase Hjc and implications for DNA recognition. Structure, 9:197-204, 2001 Cited by PubMed Abstract: Homologous recombination is a crucial mechanism in determining genetic diversity and repairing damaged chromosomes. Holliday junction is the universal DNA intermediate whose interaction with proteins is one of the major events in the recombinational process. Hjc is an archaeal endonuclease, which specifically resolves the junction DNA to produce two separate recombinant DNA duplexes. The atomic structure of Hjc should clarify the mechanisms of the specific recognition with Holliday junction and the catalytic reaction. PubMed: 11286886 DOI: 10.1016/S0969-2126(01)00576-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation