1G61
CRYSTAL STRUCTURE OF M.JANNASCHII EIF6
Summary for 1G61
| Entry DOI | 10.2210/pdb1g61/pdb |
| Related | 1G62 |
| Descriptor | TRANSLATION INITIATION FACTOR 6 (2 entities in total) |
| Functional Keywords | alpha-beta-barrel velcro closure subdomain, structural genomics, psi, protein structure initiative, new york sgx research center for structural genomics, nysgxrc, translation |
| Biological source | Methanocaldococcus jannaschii |
| Total number of polymer chains | 2 |
| Total formula weight | 48962.23 |
| Authors | Groft, C.M.,Beckmann, R.,Sali, A.,Burley, S.K.,New York SGX Research Center for Structural Genomics (NYSGXRC) (deposition date: 2000-11-02, release date: 2000-11-22, Last modification date: 2024-02-07) |
| Primary citation | Groft, C.M.,Beckmann, R.,Sali, A.,Burley, S.K. Crystal structures of ribosome anti-association factor IF6. Nat.Struct.Biol., 7:1156-1164, 2000 Cited by PubMed Abstract: Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit. PubMed: 11101899DOI: 10.1038/82017 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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