1G35

CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR, AHA024

Summary for 1G35

Entry DOI	10.2210/pdb1g35/pdb
Related	1ajv 1ajx
Descriptor	HIV-1 PROTEASE, 2-[4-(HYDROXY-METHOXY-METHYL)-BENZYL]-7-(4-HYDROXYMETHYL-BENZYL)-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-1LAMBDA6-[1,2,7]THIADIAZEPANE-4,5-DIOL (3 entities in total)
Functional Keywords	protein-inhibitor complex, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22272.28
Authors	Lindberg, J.,Unge, T. (deposition date: 2000-10-23, release date: 2001-06-06, Last modification date: 2023-08-09)
Primary citation	Schaal, W.,Karlsson, A.,Ahlsen, G.,Lindberg, J.,Andersson, H.O.,Danielson, U.H.,Classon, B.,Unge, T.,Samuelsson, B.,Hulten, J.,Hallberg, A.,Karlen, A. Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors. J.Med.Chem., 44:155-169, 2001 Cited by PubMed: 11170625 DOI: 10.1021/jm001024j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation