1AJV

HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006

Summary for 1AJV

DescriptorHIV-1 PROTEASE, 2,7-DIBENZYL-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-[1,2,7]THIADIAZEPANE-4,5-DIOL (3 entities in total)
Functional Keywordsprotease, aspartyl protease, non-peptide inhibitor, drug design, hiv-1
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03366
Total number of polymer chains2
Total molecular weight22182.2
Authors
Backbro, K.,Unge, T. (deposition date: 1997-05-11, release date: 1997-08-20, Last modification date: 2011-07-13)
Primary citation
Backbro, K.,Lowgren, S.,Osterlund, K.,Atepo, J.,Unge, T.,Hulten, J.,Bonham, N.M.,Schaal, W.,Karlen, A.,Hallberg, A.
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
J.Med.Chem., 40:898-902, 1997
PubMed: 9083478 (PDB entries with the same primary citation)
DOI: 10.1021/jm960588d
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers703.6%0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1ajv
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Molmil generated image of 1ajv
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Molmil generated image of 1ajv
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