1AJV

HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006

Summary for 1AJV

Entry DOI	10.2210/pdb1ajv/pdb
Descriptor	HIV-1 PROTEASE, 2,7-DIBENZYL-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-[1,2,7]THIADIAZEPANE-4,5-DIOL (3 entities in total)
Functional Keywords	protease, aspartyl protease, non-peptide inhibitor, drug design, hiv-1
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
Total number of polymer chains	2
Total formula weight	22182.20
Authors	Backbro, K.,Unge, T. (deposition date: 1997-05-11, release date: 1997-08-20, Last modification date: 2023-08-02)
Primary citation	Backbro, K.,Lowgren, S.,Osterlund, K.,Atepo, J.,Unge, T.,Hulten, J.,Bonham, N.M.,Schaal, W.,Karlen, A.,Hallberg, A. Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor. J.Med.Chem., 40:898-902, 1997 Cited by PubMed: 9083478 DOI: 10.1021/jm960588d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation