1G30

THROMBIN INHIBITOR COMPLEX

1G30 の概要

• エントリーDOI: 10.2210/pdb1g30/pdb
• 分子名称: PROTHROMBIN, HIRUDIN IIB, [(1-{2[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-1-METHYL-1H-BENZOIMIDAZOL-5-YL}-CYCLOPROPYL)-PYRIDIN-2-YL-METHYLENEAMINOOXY]-ACETIC ACID ETHYL ESTER, ... (5 entities in total)
• 機能のキーワード: blood coagulation, factor xa, inhibitor complexes, serine proteinase, blood coagulation cascade, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35893.88

構造登録者

Nar, H. (登録日: 2000-10-23, 公開日: 2001-10-23, 最終更新日: 2024-11-13)

主引用文献

Nar, H.,Bauer, M.,Schmid, A.,Stassen, J.M.,Wienen, W.,Priepke, H.W.,Kauffmann, I.K.,Ries, U.J.,Hauel, N.H.
Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.
Structure, 9:29-38, 2001

PubMed Abstract: A major current focus of pharmaceutical research is the development of selective inhibitors of the blood coagulation enzymes thrombin or factor Xa to be used as orally bioavailable anticoagulant drugs in thromboembolic disorders and in the prevention of venous and arterial thrombosis. Simultaneous direct inhibition of thrombin and factor Xa by synthetic proteinase inhibitors as a novel approach to antithrombotic therapy could result in potent anticoagulants with improved pharmacological properties.

PubMed: 11342132
DOI: 10.1016/S0969-2126(00)00551-7

実験手法

X-RAY DIFFRACTION (2 Å)