1FWM

Crystal structure of the thymidylate synthase R166Q mutant

Summary for 1FWM

• Entry DOI: 10.2210/pdb1fwm/pdb
• Related: 1FFL
• Descriptor: THYMIDYLATE SYNTHASE, SULFATE ION, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• Functional Keywords: methyltransferase, transferase
• Biological source: Escherichia coli
• Cellular location: Cytoplasm : P0A884
• Total number of polymer chains: 2
• Total formula weight: 62208.26

Authors

Sotelo-Mundo, R.R.,Changchien, L.,Maley, F.,Montfort, W.R. (deposition date: 2000-09-23, release date: 2003-11-11, Last modification date: 2021-11-03)

• Primary citation: Sotelo-Mundo, R.R.,Changchien, L.,Maley, F.,Montfort, W.R.; Crystal structures of thymidylate synthase mutant R166Q: Structural basis for the nearly complete loss of catalytic activity.; J.Biochem.Mol.Toxicol., 20:88-92, 2006; PubMed: 16615077; DOI: 10.1002/jbt.20122

Experimental method

X-RAY DIFFRACTION (2.2 Å)