1FQ8

X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN

Summary for 1FQ8

• Entry DOI: 10.2210/pdb1fq8/pdb
• Related: 1dp5 1fq4 1fq5 1fq6 1fq7 2jxr
• Related PRD ID: PRD_000565
• Descriptor: SACCHAROPEPSIN, beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-cyclohexyl-4,4-difluoro-3-hydroxy-5-(methylamino)-5-oxo-pentan-2-yl]amino]-1-oxo-hexan-2 -yl]amino]-1-oxo-3-phenyl-propan-2-yl]morpholine-4-carboxamide, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 37544.34

Authors

Cronin, N.B.,Badasso, M.O.,Tickle, I.J.,Dreyer, T.,Hoover, D.J.,Rosati, R.L.,Humblet, C.C.,Lunney, E.A.,Cooper, J.B. (deposition date: 2000-09-04, release date: 2000-09-20, Last modification date: 2020-07-29)

• Primary citation: Cronin, N.B.,Badasso, M.O.,J Tickle, I.,Dreyer, T.,Hoover, D.J.,Rosati, R.L.,Humblet, C.C.,Lunney, E.A.,Cooper, J.B.; X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.; J.Mol.Biol., 303:745-760, 2000; PubMed: 11061973; DOI: 10.1006/jmbi.2000.4181

Experimental method

X-RAY DIFFRACTION (2.8 Å)