1FQ4

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A

Summary for 1FQ4

• Entry DOI: 10.2210/pdb1fq4/pdb
• Related: 1dpj 1fq5 1fq6 1fq7 1fq8 2jxr
• Related PRD ID: PRD_000563
• Descriptor: SACCHAROPEPSIN, beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(2R)-1-{[(2S,3R,5R)-1-cyclohexyl-3-hydroxy-5-{[2-(morpholin-4-yl)ethyl]carbamoyl}oct-7-yn-2-yl]amino}-3-(methylsulfa nyl)-1-oxopropan-2-yl]-1H-benzimidazole-2-carboxamide, ... (5 entities in total)
• Functional Keywords: aspartic proteinase-inhibitor complex, extended beta-strand (inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 37547.42

Authors

Cronin, N.B.,Badasso, M.O.,Tickle, I.J.,Dreyer, T.,Hoover, D.J.,Rosati, R.L.,Humblet, C.C.,Lunney, E.A.,Cooper, J.B. (deposition date: 2000-09-03, release date: 2000-09-20, Last modification date: 2020-07-29)

• Primary citation: Cronin, N.B.,Badasso, M.O.,J Tickle, I.,Dreyer, T.,Hoover, D.J.,Rosati, R.L.,Humblet, C.C.,Lunney, E.A.,Cooper, J.B.; X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.; J.Mol.Biol., 303:745-760, 2000; PubMed: 11061973; DOI: 10.1006/jmbi.2000.4181

Experimental method

X-RAY DIFFRACTION (2.7 Å)