1FPU
CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Summary for 1FPU
Entry DOI | 10.2210/pdb1fpu/pdb |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL, N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-3-PYRIDINECARBOXAMIDE (3 entities in total) |
Functional Keywords | kinase, kinase inhibitor, sti-571, activation loop, transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 2 |
Total formula weight | 68251.88 |
Authors | Schindler, T.,Bornmann, W.,Pellicena, P.,Miller, W.T.,Clarkson, B.,Kuriyan, J. (deposition date: 2000-08-31, release date: 2000-09-20, Last modification date: 2024-03-13) |
Primary citation | Schindler, T.,Bornmann, W.,Pellicena, P.,Miller, W.T.,Clarkson, B.,Kuriyan, J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science, 289:1938-1942, 2000 Cited by PubMed: 10988075DOI: 10.1126/science.289.5486.1938 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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