1FM9
THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.
Summary for 1FM9
Entry DOI | 10.2210/pdb1fm9/pdb |
Related | 1FM6 |
Descriptor | RETINOIC ACID RECEPTOR RXR-ALPHA, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, STEROID RECEPTOR COACTIVATOR, ... (6 entities in total) |
Functional Keywords | the heterodimer of the nuclear receptor ligand binding domains of rxralpha and ppargamma bound respectively with 9-cis retinoic acid and gi262570 and co-activator peptides, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P19793 P37231 |
Total number of polymer chains | 4 |
Total formula weight | 64221.36 |
Authors | Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Miller, A.B.,Bledsoe, R.K.,Milburn, M.V.,Kliewer, S.A.,Willson, T.M.,Xu, H.E. (deposition date: 2000-08-16, release date: 2001-02-16, Last modification date: 2024-02-07) |
Primary citation | Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Miller, A.B.,Bledsoe, R.K.,Milburn, M.V.,Kliewer, S.A.,Willson, T.M.,Xu, H.E. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol.Cell, 5:545-555, 2000 Cited by PubMed: 10882139DOI: 10.1016/S1097-2765(00)80448-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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