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1FM6

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.

Summary for 1FM6
Entry DOI10.2210/pdb1fm6/pdb
Related1FM9
DescriptorRETINOIC ACID RECEPTOR RXR-ALPHA, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, STEROID RECEPTOR COACTIVATOR, ... (6 entities in total)
Functional Keywordsthe heterodimer of the nuclear receptor ligand binding domains of rxralpha and ppargamma bound respectively with 9-cis retinoic acid and rosiglitazone and co-activator peptides, transcription
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus : P19793 P37231
Total number of polymer chains8
Total formula weight128064.36
Authors
Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Miller, A.B.,Bledsoe, R.K.,Milburn, M.V.,Kliewer, S.A.,Willson, T.M.,Xu, H.E. (deposition date: 2000-08-16, release date: 2001-02-16, Last modification date: 2024-02-07)
Primary citationGampe Jr., R.T.,Montana, V.G.,Lambert, M.H.,Miller, A.B.,Bledsoe, R.K.,Milburn, M.V.,Kliewer, S.A.,Willson, T.M.,Xu, H.E.
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Mol.Cell, 5:545-555, 2000
Cited by
PubMed: 10882139
DOI: 10.1016/S1097-2765(00)80448-7
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

數據於2024-03-27公開中

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