1FM6
THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| U | 0003677 | molecular_function | DNA binding |
| U | 0003707 | molecular_function | nuclear steroid receptor activity |
| U | 0005634 | cellular_component | nucleus |
| U | 0006355 | biological_process | regulation of DNA-templated transcription |
| U | 0008270 | molecular_function | zinc ion binding |
| X | 0003677 | molecular_function | DNA binding |
| X | 0004879 | molecular_function | nuclear receptor activity |
| X | 0005634 | cellular_component | nucleus |
| X | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 9CR A 501 |
| Chain | Residue |
| A | ALA271 |
| A | GLN275 |
| A | TRP305 |
| A | PHE313 |
| A | ARG316 |
| A | LEU326 |
| A | ALA327 |
| A | CYS432 |
| A | HIS435 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 9CR U 502 |
| Chain | Residue |
| U | ALA271 |
| U | PHE313 |
| U | ARG316 |
| U | LEU326 |
| U | ALA327 |
| U | CYS432 |
| U | HIS435 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE BRL D 503 |
| Chain | Residue |
| D | ILE281 |
| D | PHE282 |
| D | GLY284 |
| D | CYS285 |
| D | SER289 |
| D | HIS323 |
| D | LEU330 |
| D | ILE341 |
| D | MET348 |
| D | MET364 |
| D | HIS449 |
| D | LEU453 |
| D | LEU469 |
| D | TYR473 |
| D | HOH583 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE BRL X 504 |
| Chain | Residue |
| X | PHE282 |
| X | GLY284 |
| X | CYS285 |
| X | SER289 |
| X | HIS323 |
| X | TYR327 |
| X | MET364 |
| X | HIS449 |
| X | LEU453 |
| X | TYR473 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER641 | |
| V | SER641 | |
| E | SER698 | |
| Y | SER698 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 |
| Chain | Residue | Details |
| D | SER254 | |
| U | SER259 | |
| X | SER254 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| A | SER260 | |
| U | SER260 |
