1FCV

CRYSTAL STRUCTURE OF BEE VENOM HYALURONIDASE IN COMPLEX WITH HYALURONIC ACID TETRAMER

1FCV の概要

• エントリーDOI: 10.2210/pdb1fcv/pdb
• 関連するPDBエントリー: 1FCQ 1FCU
• 分子名称: HYALURONOGLUCOSAMINIDASE, alpha-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranuronic acid (3 entities in total)
• 機能のキーワード: 7 stranded tim barrel, allergen, glycosidase family 56, hyaluronic acid, hydrolase
• 由来する生物種: Apis mellifera (honey bee)
• 細胞内の位置: Secreted: Q08169
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41854.10

構造登録者

Markovic-Housley, Z.,Miglierini, G.,Soldatova, L.,Rizkallah, P.J.,Mueller, U.,Schirmer, T. (登録日: 2000-07-19, 公開日: 2001-10-01, 最終更新日: 2024-10-30)

主引用文献

Markovic-Housley, Z.,Miglierini, G.,Soldatova, L.,Rizkallah, P.J.,Muller, U.,Schirmer, T.
Crystal structure of hyaluronidase, a major allergen of bee venom.
Structure Fold.Des., 8:1025-1035, 2000

PubMed Abstract: Hyaluronic acid (HA) is the most abundant glycosaminoglycan of vertebrate extracellular spaces and is specifically degraded by a beta-1,4 glycosidase. Bee venom hyaluronidase (Hya) shares 30% sequence identity with human hyaluronidases, which are involved in fertilization and the turnover of HA. On the basis of sequence similarity, mammalian enzymes and Hya are assigned to glycosidase family 56 for which no structure has been reported yet.

PubMed: 11080624
DOI: 10.1016/S0969-2126(00)00511-6

実験手法

X-RAY DIFFRACTION (2.65 Å)