1FCV
CRYSTAL STRUCTURE OF BEE VENOM HYALURONIDASE IN COMPLEX WITH HYALURONIC ACID TETRAMER
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004415 | molecular_function | hyalurononglucosaminidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006952 | biological_process | defense response |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030214 | biological_process | hyaluronan catabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:11080624 |
| Chain | Residue | Details |
| A | GLU113 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN83 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10998264 |
| Chain | Residue | Details |
| A | ASN231 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1fcq |
| Chain | Residue | Details |
| A | ASP111 | |
| A | GLU113 | |
| A | TYR184 | |
| A | TYR227 | |
| A | TRP301 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 616 |
| Chain | Residue | Details |
| A | ASP111 | electrostatic stabiliser, modifies pKa, steric role |
| A | GLU113 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | TYR184 | steric role |
| A | TYR227 | electrostatic stabiliser, steric role, transition state stabiliser |
| A | TRP301 | steric role |
