1FAP
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
Summary for 1FAP
Entry DOI | 10.2210/pdb1fap/pdb |
Descriptor | FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ... (4 entities in total) |
Functional Keywords | fkbp12, frap, rapamycin, complex (isomerase-kinase), complex (isomerase-kinase) complex, complex (isomerase/kinase) |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 24239.81 |
Authors | Choi, J.,Chen, J.,Schreiber, S.L.,Clardy, J. (deposition date: 1996-03-15, release date: 1997-07-23, Last modification date: 2024-02-07) |
Primary citation | Choi, J.,Chen, J.,Schreiber, S.L.,Clardy, J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science, 273:239-242, 1996 Cited by PubMed: 8662507PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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